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CVL006 + pemetrexed + carboplatin
- Development stage
- Phase 2
- Lead developer
- Convalife Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
CVL006 + pemetrexed + carboplatin is an investigational combination regimen studied in phase I/II clinical trials for advanced solid tumors, including non-small cell lung cancer, malignant pleural mesothelioma, and other cancers. CVL006 is an experimental agent evaluated for its safety, tolerability, pharmacokinetics, and preliminary efficacy in combination with standard chemotherapeutics pemetrexed and carboplatin. Pemetrexed is a folate antimetabolite, and carboplatin is a platinum-based alkylating agent; both disrupt cell division and DNA replication in tumor cells. The mechanism and molecular target of CVL006 are not publicly disclosed as of the current data. This multi-drug regimen is administered intravenously and aims to enhance the anti-tumor effects beyond standard chemotherapy[3][1][5][6].
- Other names
- pemetrexed + carboplatin
02
Targets
ATIC (Aminoimidazole carboxamide ribonucleotide transformylase)DNADHFR (Dihydrofolate reductase)GART (GAR transformylase)CD274 (Programmed cell death protein 1 ligand 1)TS (Thymidylate synthase)VEGFA (Vascular endothelial growth factor A)
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