CVS-16

CVS-16 (also known as 10b) is a small molecule vinyl sulfone analogue of lysophosphatidylcholine that acts as a potent, irreversible inhibitor of autotaxin (ATX). Autotaxin is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP2) that facilitates the removal of a choline headgroup from lysophosphatidylcholine (LPC) to yield lysophosphatidic acid (LPA), a potent lipid stimulator of tumorigenesis, motility, and angiogenesis. Developed by researchers at the University of Georgia and the University of Utah, CVS-16 has demonstrated significant biological activity in melanoma models, including the inhibition of cell migration and wound closure in vitro. In vivo studies have shown that CVS-16 can significantly inhibit melanoma progression by preventing angiogenesis, highlighting its potential as a therapeutic agent for malignant progression.

Other names

vinyl sulfone analogue of lysophosphatidylcholine