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CX-801

Development stage: Phase 1
Lead developer: CytomX
Modality: Engineered Antibody Formats → Antibody-Based Therapeutics, Cytokines & Interferons → Recombinant Proteins and Enzymes
Administration: Intravenous

Overview

CX-801 is a dually masked, conditionally activated interferon alpha-2b (IFNα2b) Probody cytokine developed by CytomX Therapeutics. It is designed to harness the immune-stimulating and anti-cancer properties of interferon alpha-2b while minimizing systemic toxicities by localizing its activity within tumors. The masking technology enables targeted activation in the tumor microenvironment, potentially improving tolerability and efficacy compared to unmodified IFNα2b. CX-801 is being evaluated as both monotherapy and in combination with pembrolizumab (an anti-PD1 checkpoint inhibitor) for advanced solid tumors, including metastatic melanoma, renal cell carcinoma, and head and neck squamous cell carcinoma[1][3][5][8].

Other names: Protease-activatable interferon alpha-2b

Targets

IFNAR (Immune system modulation via type I interferon receptor)

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