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CX3CL1-Wnt3a-MSC
- Development stage
- Preclinical
- Lead developer
- Jinan University
- Modality
- Gene Therapies, Stem Cell Therapies → Cell Therapies
- Administration
- Parenteral
01
Overview
**CX3CL1-Wnt3a-MSC** is an experimental, adenovirally engineered bone marrow mesenchymal stem-cell therapy designed to secrete CX3CL1 and Wnt3a following transplantation into the brain. In APPswe/PSEN1dE9 mouse models of early Alzheimer's disease, the product improved learning and memory, reduced microglial neurotoxicity, promoted hippocampal neurogenesis, and was associated with PI3K/AKT signaling, inhibition of glycogen synthase kinase 3 beta activity, and Wnt3a-beta-catenin signaling. It is a preclinical research-stage cell-based therapeutic and has not been identified as a marketed or clinical-stage product. ([alzped.nia.nih.gov](https://alzped.nia.nih.gov/delivery-exogenous-proteins))
- Other names
- CX3CL1-Wnt3a-mesenchymal stem cellsCX-3CL1-Wnt3a-mesenchymal stem cellsCX 3CL1-Wnt3a-mesenchymal stem cells
02
Targets
CX3CR1 (C-X3-C motif chemokine receptor 1)FZD (Frizzled receptor family)
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