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CXCR7 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
CXCR7 siRNA is a research-grade small interfering RNA (siRNA) molecule designed to silence the expression of the CXC chemokine receptor 7 (CXCR7), also known as atypical chemokine receptor 3 (ACKR3). CXCR7 is a G protein-coupled receptor that primarily signals through the β-arrestin pathway and binds ligands such as CXCL11 and CXCL12. In preclinical studies, CXCR7 siRNA is utilized to investigate the receptor's role in tumor progression, epithelial-to-mesenchymal transition (EMT), and metastasis across various malignancies, including renal, prostate, and breast cancers. By knocking down CXCR7 expression, researchers can evaluate the therapeutic potential of CXCR7 antagonism in cancer, inflammatory diseases, and neurological disorders.
- Other names
- ACKR3 siRNAACKR-3 siRNAACKR 3 siRNACXC chemokine receptor 7 siRNA
02
Targets
CXCR7 (CXC chemokine receptor 7)
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