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CY-9
- Development stage
- Preclinical
- Lead developer
- Nankai University
- Modality
- Small Molecules
- Administration
- Oral, Intravenous, Intraperitoneal
01
Overview
CY-9 is a synthetic micheliolide analogue developed as an inhibitor of cancer stem cells (CSCs) and the NLRP3 inflammasome. Co-developed by researchers at the University of Michigan and Nankai University, CY-9 targets breast cancer and breast cancer stem cells by reducing the population of Aldefluor-positive cells, inhibiting tumorsphere formation, and depleting nuclear NF-κB levels. Additionally, CY-9 acts as an inhibitor of the NLRP3 inflammasome, suppressing caspase-1 cleavage and the release of mature interleukin-1β (IL-1β) in inflammatory models. Its activity is partially mediated by reactive oxygen species (ROS) generation and interaction with biologically relevant cysteines.
- Other names
- micheliolide analog CY-9micheliolide analogue CY-9
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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