Drug intelligence / Profile preview

Cy5-Ab-SS-SN38

Development stage: Unknown
Lead developer: Ariel University
Modality: Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes

Overview

Cy5-Ab-SS-SN38: sourced facts only. name: "Here, we report on the design, synthesis, and biological evaluation of a new theranostic antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific antibody trastuzumab (Ab) connected to the near infrared (NIR) pentamethine cyanine dye Cy5 and SN38, which is a bioactive metabolite of the anticancer drug irinotecan." [PMID:36966651]; target: "Here, we report on the design, synthesis, and biological evaluation of a new theranostic antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific antibody trastuzumab (Ab) connected to the near infrared (NIR) pentamethine cyanine dye Cy5 and SN38, which is a bioactive metabolite of the anticancer drug irinotecan." [PMID:36966651]; developer: "Department of Chemical Sciences, The Faculty of Natural Sciences, Ariel University, Ariel, 40700, Israel. Electronic address: [email protected]." [PMID:36966651]; modality: "Here, we report on the design, synthesis, and biological evaluation of a new theranostic antibody drug conjugate (ADC), Cy5-Ab-SS-SN38, that consists of the HER2-specific antibody trastuzumab (Ab) connected to the near infrared (NIR) pentamethine cyanine dye Cy5 and SN38, which is a bioactive metabolite of the anticancer drug irinotecan." [PMID:36966651]

Targets

ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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