Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
cyanocobalamin + leucovorin + omega-3 fatty acids + acetylcysteine
- Development stage
- Unknown
- Lead developer
- Hôpital Sainte-Anne
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
"Vitamin B12 + folinic acid + omega 3 + N-acetyl cysteine" is a personalized neuroprotective combination supplement regimen investigated in the PsyCARE trial (NCT05796401). This multi-component intervention is tailored to an individual's biological profile and consists of cyanocobalamin (Vitamin B12), leucovorin (folinic acid), omega-3 fatty acids (EPA and DHA), and acetylcysteine (NAC). The regimen targets biological pathways implicated in early psychosis, including oxidative stress (via NAC as a glutathione precursor), neuroinflammation, glutamatergic signaling (NMDA receptor modulation), and homocysteine metabolism (via B12 and folinic acid). It is used as an adjunct to treatment as usual (TAU) in adolescents and young adults with first-episode psychosis or those at ultra-high risk for developing a chronic psychotic disorder.
- Other names
- vitamin B12 + folinic acid + omega 3 + N-acetyl cysteinePsyCARE interventioncomposite personalised care
02
Targets
SLC7A11 (Cystine-Glutamate Antiporter)MTR (Methionine synthase)FFAR4 (Free fatty acid receptor 4)
Beyond the preview
Go deeper on cyanocobalamin + leucovorin + omega-3 fatty acids + acetylcysteine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cyanocobalamin + leucovorin + omega-3 fatty acids + acetylcysteine.