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cyc-dezocine
- Development stage
- Preclinical
- Lead developer
- Cyclerion Therapeutics
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intranasal
01
Overview
Cyc-dezocine is a novel formulation of dezocine being investigated as a therapeutic for opioid use disorder. Based on the provided preclinical publication, it is designed for intraperitoneal or intranasal administration and reduced oxycodone self-administration in male and female rat models. Dezocine is an opioid analgesic with partial agonist activity at the mu opioid receptor and pharmacology involving the kappa opioid receptor; cyc-dezocine appears to leverage this opioid receptor activity in a reformulated product intended to decrease voluntary opioid intake rather than to serve as a conventional perioperative analgesic.
- Other names
- cyc-dezocine
02
Targets
DOR (Opioid Receptor Delta 1)SERT (Sodium-dependent serotonin transporter)KOR (Kappa opioid receptor)σR (Sigma receptors)MOR (Mu opioid receptor)NET (Norepinephrine Transporter)
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