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CyclAGel
- Development stage
- Unknown
- Lead developer
- Zhaoke Ophthalmology
- Modality
- Small Molecules, Hydrogel Systems → Drug Delivery Systems
- Administration
- Ophthalmic
01
Overview
CyclAGel is an innovative ophthalmic hydrogel formulation of cyclosporine A (0.05%) developed by Zhaoke Ophthalmology for the treatment of moderate to severe dry eye disease (keratoconjunctivitis sicca). As a small molecule immunosuppressant, it targets inflammatory pathways involved in the pathogenesis of dry eye. The proprietary hydrogel formulation is designed to provide a superior pharmacokinetic profile compared to traditional emulsions like Restasis, enabling once-daily (QD) nocturnal administration. In the Phase III COSMO trial, CyclAGel demonstrated a statistically significant improvement in the inferior fluorescein corneal staining score (ICSS) compared to a vehicle control.
- Other names
- Cyclosporine A Ophthalmic GelCsA Ophthalmic GelCsA eye gel
02
Targets
CN (Calcineurin)PPIA (Peptidyl-prolyl cis-trans isomerase A)
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