cyclic diadenosine monophosphate

Cyclic diadenosine monophosphate (c-di-AMP) is a naturally occurring bacterial second messenger and cyclic dinucleotide that plays a critical role in prokaryotic physiology, including cell wall homeostasis, potassium transport, osmotic stress response, and DNA integrity. In mammalian hosts, c-di-AMP acts as a potent pathogen-associated molecular pattern (PAMP) that directly binds to and activates the Stimulator of Interferon Genes (STING) pathway, triggering a type I interferon response and activating innate immunity. Due to its ability to stimulate robust humoral and cellular immune responses, c-di-AMP is widely utilized as a research tool and is being investigated as a mucosal vaccine adjuvant and immunotherapeutic agent.

Other names

3',5'-cyclic di-adenosine monophosphate3',5'-cyclic diadenylic acidbis-(3',5')-cyclic diadenosine monophosphatebis-(3',5')-cyclic dimeric adenosine monophosphatec-di-AMPcyclic di-adenosine monophosphatecyclic di-adenylate monophosphatecyclic diadenylatecyclic diadenylate monophosphate