cyclic GMP-AMP

**cyclic GMP-AMP** is a cyclic purine dinucleotide composed of AMP and GMP units cyclized via 3',5'-linkages[1]. It is an endogenous second messenger produced by the enzyme cyclic GMP-AMP synthase (cGAS) when cGAS detects abnormal cytoplasmic DNA[4][6]. Once generated, cyclic GMP-AMP binds to the stimulator of interferon genes (STING) protein, activating a signaling pathway that results in type I interferon and cytokine production, thereby triggering a robust innate immune response[4][6]. Cyclic GMP-AMP has notable roles in antiviral defense, cancer immunotherapy (as a STING agonist), and is under investigation as a therapeutic agent and vaccine adjuvant[6][8].

Other names

3',5'-cyclic GMP-AMPcyclic GMP-AMPc-GpAp sodium salt3',3'-cyclic guanosine monophosphate-adenosine monophosphateCyclic [G(3',5')pA(3',5')p]2-amino-9-[(1S,6R,8R,9R,10S,15R,17R,18R)-17-(6-aminopurin-9-yl)-3,9,12,18-tetrahydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3|E5,12|E5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]-1H-purin-6-one