cyclic STAT3 decoy

cyclic STAT3 decoy (CS3D) is a synthetically engineered cyclic double-stranded oligonucleotide (DN4, DS18 series) designed to selectively bind and inhibit STAT3, a transcription factor implicated in oncogenesis and therapeutic resistance[1][2][3][4]. The decoy mimics the STAT3 response element, competitively binding phosphorylated STAT3 homodimers, preventing their nuclear entry and oncogenic gene transcription by target genes such as c-Myc, Bcl-xL, and cyclin D1; it also induces STAT3 ubiquitination and degradation[1][4]. This approach overcomes previous drug instability by linking oligonucleotide strands with spacers, greatly enhancing serum half-life and stability[2]. The cyclic STAT3 decoy has shown robust anti-tumor effects and safety in preclinical models of head and neck squamous cell carcinoma (HNSCC) and non-small cell lung carcinoma (NSCLC), including resistant subtypes[1][3][4].

Other names

cyclic STAT3 decoyCS3DCS-3DCS 3DSTAT3 cyclic oligonucleotide decoySTAT-3 cyclic oligonucleotide decoySTAT 3 cyclic oligonucleotide decoySTAT3 cODN decoySTAT-3 cODN decoySTAT 3 cODN decoy