Cyclin K degrader

RejuvenRx's Cyclin K degrader is a preclinical small molecule designed to induce the targeted degradation of Cyclin K (CCNK). Cyclin K is a regulatory subunit that associates with the cyclin-dependent kinases CDK12 and CDK13, which are essential for the transcription of genes involved in the DNA damage response (DDR) and other critical cellular processes. By utilizing a targeted protein degradation (TPD) approach, this compound triggers the proteasomal degradation of Cyclin K, leading to the functional loss of the CDK12/13 complex. This mechanism results in the downregulation of DDR-related transcripts, genomic instability, and selective apoptosis in cancer cells, particularly those that are transcriptionally addicted or have existing DDR deficiencies.

Other names

CCNK degrader