Cyclin-K Molecular Glue

Cyclin-K Molecular Glue is a novel targeted protein degrader developed by iLeadBMS for oncology indications. It functions as a molecular glue that binds to cyclin-dependent kinase 12 (CDK12) and promotes the recruitment of the DDB1-containing E3 ubiquitin ligase complex. This interaction leads to selective ubiquitination and proteasomal degradation of cyclin K, a regulatory protein involved in cell cycle control and gene expression associated with cancer progression[3][6][7][8]. By degrading cyclin K, this drug disrupts the CDK12–cyclin K complex critical for tumor cell survival and proliferation. The compound has demonstrated potent growth inhibition in HER2-negative gastric cancer cells in vitro and has received Orphan Drug Designation from the FDA for gastric cancer[3]. The approach offers unique therapeutic opportunities distinct from traditional CDK inhibitors by leveraging targeted protein degradation rather than simple enzymatic inhibition[5].

Brand names

Cyclin-K Molecular Glue

Other names

Cyclin-K MGcyclin K molecular glue degraderCDK12-cyclin K molecular glueCDK-12-cyclin K molecular glueCDK 12-cyclin K molecular gluecyclin K degrader