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Cyclo-Z
- Development stage
- Unknown
- Lead developer
- VA Office of Research & Development
- Modality
- Peptides, Small Molecules
- Administration
- Oral
01
Overview
Cyclo-Z is an investigational combination therapy developed by the VA Office of Research and Development for the treatment of type 2 diabetes mellitus. It consists of zinc and the cyclic dipeptide cyclo(histidyl-proline) (CHP), a naturally occurring metabolite of thyrotropin-releasing hormone. CHP acts as a zinc-binding ligand that facilitates the intestinal absorption and cellular uptake of zinc. Zinc is a critical cofactor for numerous enzymes involved in glucose metabolism and is essential for the proper synthesis, storage, and secretion of insulin. Furthermore, zinc has been shown to exert insulin-mimetic effects by activating the insulin receptor and downstream signaling pathways. By optimizing zinc homeostasis, Cyclo-Z aims to improve glycemic control and insulin sensitivity in patients with type 2 diabetes.
- Other names
- Cyclo(his-pro) plus zincCyclo-his-pro plus zincCHP-Zinc
02
Targets
INSR (Insulin receptor)
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