Drug intelligence / Profile preview

cyclodynon

Development stage
Phase 4
Lead developer
Bionorica
Modality
Small Molecules
Administration
Oral
01

Overview

Cyclodynon is a herbal medicinal product containing a standardized dry extract of the fruit of *Vitex agnus-castus* (chaste tree), specifically the BNO 1095 extract. It is primarily used for the treatment of menstrual cycle disorders such as premenstrual syndrome (PMS), mastodynia (breast pain), dysmenorrhea, and other menstrual irregularities. The mechanism of action involves dopaminergic activity at dopamine receptor subtype 2 in lactotrophic pituitary cells, leading to inhibition of prolactin secretion. This effect helps reduce symptoms associated with mild hyperprolactinemia and related menstrual complaints. Cyclodynon has also demonstrated anti-inflammatory properties by inhibiting oxytocin-induced uterine contractions and suppressing inflammatory mediators in vitro[1][4][5][6][10].

Brand names
CyclodynonCyclodynone
Other names
Vitex agnus-castus extract BNO 1095chaste tree fruit extractchasteberry extract
02

Targets

ESR1 (ERα)Oxytocin receptorDRD2 (Dopamine D2 Receptor)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)

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