cyclohexyl-norstatine

Cyclohexyl-norstatine is a synthetic small molecule classified as a beta amino acid derivative. It has the chemical formula C13H25NO3 and a molecular weight of approximately 243.34 g/mol[1][2][6]. Cyclohexyl-norstatine itself is not an approved drug but has been used as a building block in the synthesis of experimental renin inhibitors, such as KRI 1314, which are being investigated for their antihypertensive properties[5][8]. The mechanism of action for these derivatives involves inhibition of human plasma renin, an enzyme critical to the regulation of blood pressure via the renin–angiotensin system. Cyclohexyl-norstatine-containing compounds have demonstrated potent in vitro and in vivo activity against renin, suggesting potential utility in hypertension management[5].

Other names

cyclohexyl-norstatinepropan-2-yl (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutanoate