cycloleucine

Cycloleucine is a non-metabolizable synthetic amino acid formed by the cyclization of leucine. It acts as a specific and reversible inhibitor of nucleic acid methylation, particularly by inhibiting S‑adenosyl-methionine-mediated methylation. Cycloleucine is also an antagonist at the glycine site of the NMDA (N-methyl-D-aspartic acid) receptor and has been shown to have cytostatic, antineoplastic, immunosuppressive, and anxiolytic effects in preclinical studies. It is widely used as a research tool in neuroscience, protein synthesis studies, plant biology, and biochemical research to investigate enzyme mechanisms and metabolic pathways[1][2][3][4][5][10].

Other names

cycloleucine1-amino-1-cyclopentanecarboxylic acid1-aminocyclopentane-1-carboxylic acid1-amino cyclopentane carboxylic acidCyclo-leucineCycloleucin