Drug intelligence / Profile preview

cyclophosphamide + fluorouracil + vinorelbine

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Intravenous
01

Overview

A chemotherapy combination regimen consisting of cyclophosphamide, 5-fluorouracil, and vinorelbine used primarily for the treatment of locally advanced or metastatic breast cancer. This combination has shown efficacy comparable to anthracycline-containing regimens while maintaining a manageable toxicity profile, making it suitable for patients who have been extensively exposed to anthracyclines during adjuvant therapy or who have contraindications to their use.

02

Targets

MicrotubuleDNATS (Thymidylate synthase)

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