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Drug intelligence / Profile preview
cyclophosphamide + pemetrexed + 5-fluorouracil
- Development stage
- Phase 2
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
cyclophosphamide + pemetrexed + 5-fluorouracil is a combination chemotherapy regimen being evaluated by West China Hospital in a Phase 2 clinical trial. This regimen is part of a precision medicine study where treatment selection for locally advanced or metastatic poorly differentiated or anaplastic thyroid cancer is guided by in-vitro drug sensitivity testing using tumor-derived organoids. The combination consists of cyclophosphamide, an alkylating agent that cross-links DNA; pemetrexed, a multi-targeted antifolate that inhibits enzymes involved in purine and pyrimidine synthesis; and 5-fluorouracil, a pyrimidine analog that inhibits thymidylate synthase. This approach aims to improve outcomes in rare and aggressive thyroid cancers that have failed conventional therapies.
- Other names
- Cyclophosphamide+Pemetrexed+5-Fluorouracil
02
Targets
DNADHFR (Dihydrofolate reductase)GART (GAR transformylase)TS (Thymidylate synthase)
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