cyclophosphamide + doxorubicin + filgrastim

This is a combination regimen consisting of three agents:\n- **Cyclophosphamide** is an alkylating agent that interferes with DNA replication and transcription, leading to cell death. It is primarily used as an antineoplastic in various cancers.\n- **Doxorubicin** is an anthracycline antibiotic that intercalates into DNA, inhibits topoisomerase II, and generates free radicals, resulting in cytotoxicity against rapidly dividing cells.\n- **Filgrastim** is a recombinant human granulocyte colony-stimulating factor (G-CSF) that stimulates the production of neutrophils from the bone marrow. It reduces the incidence and duration of neutropenia associated with myelosuppressive chemotherapy.\n\nThis combination may be used in regimens for hematologic malignancies or solid tumors where myelosuppression risk requires supportive care with G-CSF to reduce infection risk[1][2][5].

Other names

doxorubicin + cyclophosphamide + filgrastimdose-dense ACddAC regimenAC regimen with G-CSF support