Drug intelligence / Profile preview

cyclophosphamide + doxorubicin + methotrexate + cytarabine

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Intravenous, Intrathecal (methotrexate And Cytarabine Can Be Given This Way), Oral (methotrexate And Cyclophosphamide Occasionally)
01

Overview

This drug is a **multi-agent chemotherapy combination** composed of cyclophosphamide, doxorubicin, methotrexate, and cytarabine. Each component is a cytotoxic small molecule agent, commonly used in oncology: cyclophosphamide is an alkylating agent that cross-links DNA; doxorubicin is an anthracycline antibiotic that intercalates DNA and inhibits topoisomerase II; methotrexate is an anti-folate that inhibits dihydrofolate reductase, disrupting DNA synthesis; cytarabine is a nucleoside analog that inhibits DNA polymerase. While several two- and three-drug combinations from these components are standard (e.g., CHOP, AC, CODOX-M, etc.), there is no established, named, or widely recognized four-drug regimen using only these four agents together as a canonical protocol in adult or pediatric oncology based on present evidence.

02

Targets

DNA polymerase familyDHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)DNA

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