Drug intelligence / Profile preview

cyclophosphamide + epirubicin + gemcitabine + paclitaxel + trastuzumab

Development stage
Preclinical
Lead developer
Takeda
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

This is a combination chemotherapy regimen that includes multiple anticancer agents with different mechanisms of action. The combination includes: - Cyclophosphamide: An alkylating agent that works by damaging DNA and preventing cancer cell replication - Epirubicin: An anthracycline antibiotic that intercalates with DNA and inhibits topoisomerase II - Gemcitabine: A nucleoside analog that inhibits DNA synthesis - Paclitaxel: A taxane that stabilizes microtubules, preventing cell division - Trastuzumab (Herceptin): A monoclonal antibody that targets HER2 receptors This combination is likely used for HER2-positive breast cancer treatment, as trastuzumab specifically targets the HER2 protein overexpressed in certain breast cancers.

02

Targets

DNA polymerase familyRNR (Ribonucleotide reductase)ERBB2 (Erb-b2 receptor tyrosine kinase 2)TOP2A (DNA topoisomerase II)DNATUBB (Tubulin (alpha and beta subunits))

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