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cyclophosphamide + melphalan + thiotepa

Development stage: Unknown
Lead developer: Takeda
Modality: Small Molecules
Administration: Intravenous

Overview

A combination chemotherapy regimen consisting of three alkylating agents (cyclophosphamide, melphalan, and thiotepa) used primarily as a high-dose conditioning treatment before autologous stem cell transplantation. This combination has been studied in various hematological malignancies including non-Hodgkin lymphoma, Hodgkin lymphoma, and primary central nervous system lymphoma, as well as in metastatic breast cancer. The regimen works through DNA alkylation and cross-linking, preventing cell division and leading to cell death, particularly in rapidly dividing cancer cells.

Targets

DNA

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