Drug intelligence / Profile preview

cyclophosphamide + methotrexate + fluorouracil + vincristine + prednisone + vinblastine + doxorubicin + thiotepa + fluoxymesterone

Development stage
Unknown
Lead developer
Takeda
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular, Subcutaneous, Intrathecal, Intravesical, Intracavitary
01

Overview

This is a multi-agent chemotherapy combination consisting of nine drugs: cyclophosphamide, methotrexate, fluorouracil (5-FU), vincristine, prednisone, vinblastine, doxorubicin (also known as Adriamycin), thiotepa, and fluoxymesterone. Each component has a distinct mechanism of action targeting cancer cells through different pathways: - Cyclophosphamide is an alkylating agent that crosslinks DNA strands to inhibit cell replication. - Methotrexate is an antimetabolite that inhibits dihydrofolate reductase and disrupts DNA synthesis. - Fluorouracil (5-FU) is a pyrimidine analog that interferes with DNA and RNA synthesis by inhibiting thymidylate synthase. - Vincristine and vinblastine are vinca alkaloids that inhibit microtubule formation during mitosis. - Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties; it can induce apoptosis in certain cancer cells. - Doxorubicin is an anthracycline antibiotic that intercalates into DNA and inhibits topoisomerase II activity leading to double-strand breaks. - Thiotepa is an alkylating agent causing crosslinking of DNA strands. - Fluoxymesterone is an androgenic steroid sometimes used for its palliative effects in certain cancers. This combination would be considered highly intensive polychemotherapy. While several subsets of these drugs are used together in established regimens for breast cancer or lymphoma (such as CMF or CHOP), this exact nine-drug combination does not correspond to any standard named regimen but represents a broad-spectrum cytotoxic approach likely intended for aggressive malignancies.

02

Targets

TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)DNATUBB (Tubulin (alpha and beta subunits))AR (Adrenergic receptors)

Beyond the preview

Go deeper on cyclophosphamide + methotrexate + fluorouracil + vincristine + prednisone + vinblastine + doxorubicin + thiotepa + fluoxymesterone.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on cyclophosphamide + methotrexate + fluorouracil + vincristine + prednisone + vinblastine + doxorubicin + thiotepa + fluoxymesterone.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call