cyclophosphamide + methylprednisolone

A combination therapy consisting of cyclophosphamide, an alkylating agent, and methylprednisolone, a corticosteroid. This combination is primarily used for treating lupus nephritis and other autoimmune conditions. The therapy works through cyclophosphamide's DNA-damaging effects on rapidly dividing cells and immune system suppression, combined with methylprednisolone's anti-inflammatory and immunosuppressive properties. Clinical trials have shown that this combination may be more effective than either drug alone for certain conditions, particularly in achieving quicker time to renal response in lupus nephritis.