cyclophosphamide followed by methotrexate or azathioprine with glucocorticoids

This is a combination therapy regimen used primarily for treating steroid-refractory Crohn's disease and other inflammatory conditions. The treatment typically begins with cyclophosphamide pulse therapy (intravenous administration of 750 mg cyclophosphamide monthly), followed by maintenance therapy with either methotrexate or azathioprine, often in combination with glucocorticoids. This approach aims to achieve rapid remission with cyclophosphamide and maintain long-term response with the immunosuppressive agents. The combination has shown effectiveness in inducing remission in patients who did not respond to standard glucocorticoid therapy alone.

Other names

cyclophosphamide pulse therapy followed by azathioprine or methotrexate