Cyclopiazonic acid

Cyclopiazonic acid is a fungal secondary metabolite belonging to the class of organic compounds known as 3-alkylindoles. It is produced by certain species of Aspergillus and Penicillium fungi. Cyclopiazonic acid acts as a potent inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA), disrupting calcium homeostasis in cells. It is primarily studied as a mycotoxin due to its presence in contaminated food products and its toxic effects on animals and humans. There are no approved pharmaceutical uses for cyclopiazonic acid; it is considered an experimental compound for research purposes only[1][2].

Other names

(6AR,11AS,11BR)-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-11-onea-cyclopiazonic acid9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one 10-acetyl-2,6,6a ,7 ,11a ,11b -hexahydro - 11-hydroxy - 7 ,7-dimethyl-, (6aR , 11aS , 11bR )-