cyclopidide

Cyclopidide (SHR7331) is a small molecule inhibitor of phosphodiesterase 4 (PDE4) developed by Jiangsu Hengrui Medicine. PDE4 is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP), a key second messenger in inflammatory and cell signaling pathways. By inhibiting PDE4, cyclopidide increases intracellular cAMP levels, which can lead to the suppression of pro-inflammatory cytokines and the induction of apoptosis in certain cancer cells. Although PDE4 inhibitors are more commonly associated with inflammatory diseases such as psoriasis and atopic dermatitis, cyclopidide has been investigated in Phase I clinical trials for the treatment of advanced solid tumors, exploring its potential to inhibit tumor cell proliferation and modulate the tumor microenvironment.

Other names

环吡地尔