cycloprodigiosin hydrochloride

Cycloprodigiosin hydrochloride is a **stable red fluorescent pigment** isolated from the marine bacterium Pseudoalteromonas denitrificans and related species. It belongs to the prodigiosin family of **tripyrrole alkaloids** and is characterized by a cyclized prodiginine structure. Cycloprodigiosin hydrochloride exhibits **potent antimalarial activity**—with in vitro nanomolar efficacy against Plasmodium falciparum, surpassing chloroquine—and retains activity in vivo. It has also demonstrated **selective anticancer effects** in vitro against various cancer cell lines, as well as immunosuppressive and pro-apoptotic effects on T cells. Its biological activities are thought to arise from its ability to bind and transport ions across membranes and interaction with targets such as B-cell lymphoma 2 (Bcl-2) proteins, though its exact mechanism of action remains incompletely defined[1][2][3][5].

Other names

cPrG·HClcPrG*HClcycloprodigiosin·HCl