cyclosporine (Zhaoke Ophthalmology)

Cyclosporine (specifically the formulation developed by Zhaoke Ophthalmology) is a calcineurin inhibitor immunosuppressant used for the treatment of moderate to severe dry eye disease. It works by binding to cyclophilin within T-lymphocytes, forming a complex that inhibits the phosphatase activity of calcineurin. This inhibition prevents the translocation of the nuclear factor of activated T-cells (NFAT), thereby suppressing the production of pro-inflammatory cytokines such as interleukin-2 (IL-2). In the context of dry eye disease, this mechanism reduces immune-mediated inflammation of the ocular surface and lacrimal glands, promoting natural tear production. Zhaoke's formulation is a 0.05% ophthalmic gel designed to improve the bioavailability and residence time of the drug on the eye compared to traditional emulsions, potentially allowing for improved efficacy and patient comfort.

Brand names

兆科舒Zhaoke Shu

Other names

Cyclosporine A ophthalmic gelCsA ophthalmic gelCyclosporine ACsA