cyclotheonamide a

Cyclotheonamide A is a naturally occurring cyclic peptide isolated from the marine sponge Theonella. It features a unique structure with a cyclic arrangement of amino acids and has attracted interest in medicinal chemistry due to its potential pharmacological properties—including antimicrobial and cytotoxic effects. Cyclotheonamide A is notable for its ability to inhibit specific enzymes and cellular processes; it has been studied as an inhibitor of serine proteases such as trypsin and thrombin by binding to their active sites. Its complex structure contributes to its biological activity but also presents challenges for extraction and synthesis. Cyclotheonamide A remains an experimental compound with no approved clinical indications[1][2][5][6].

Other names

2Y1TEH8EW7UNII-2Y1TEH8EW7UNII2Y1TEH8EW7UNII 2Y1TEH8EW7129033-04-1CYCLOTHEONAMIDE A [MI]3-((4-Amino-5-(4-hydroxyphenyl)-1-oxo-2-pentenyl)amino)-N-formyl-L-alanyl-D-prolyl-6-((aminoiminomethyl)amino)-2-oxo-3-aminohexanoyl-L-phenylalanine cyclic (4–1)-peptideN-[(3S,7E,9S,12R,16S,19S)-12-benzyl-16-[3-(diaminomethylideneamino)propyl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,15,18-hexaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos‑7-en‑3-yl]formamide