cyclovirobuxine D

Cyclovirobuxine D is a **steroidal alkaloid** extracted from *Buxus microphylla* and *Buxus sinica*, traditional Chinese medicinal plants[1][3][6]. It is historically used as a cardiovascular drug in China to treat coronary heart disease, angina, arrhythmias, and heart failure[6]. Cyclovirobuxine D demonstrates pronounced **analgesic** effects in inflammatory and neuropathic pain models in mice, primarily by inhibiting **voltage-gated calcium channels (Ca_v_3.2 > Ca_v_2.2)**[1]. It also has emerging **anticancer properties**, inducing apoptosis and mitochondrial dysfunction in various cancer cell lines—mechanistically acting via pathways such as **CTHRC1-AKT/ERK-Snail**, **EGFR-FAK-AKT/ERK1/2-Slug**, and **Akt/mTOR**, leading to cell death by apoptosis or autophagy[3][7][9]. Its mechanism in cardioprotection may involve antioxidant and myocardial protective effects[6].

Brand names

Huangyangning (in compound Chinese patent medicines, as main active)cyclovirobuxine D

Other names

bebuxinecyclobuxine DCYCLOVIROBUXINEcyclovirobuxinum D9,19-cyclopregnan-16-ol, 4,4,14-trimethyl-3,20-bis(methylamino)-4,4,14-trimethyl-3alpha,20-bis(methylamino)-9,19-cyclo-5alpha-pregnan-16-ol