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CYD dengue virus serotype 4 live attenuated antigen

Development stage: Unknown
Lead developer: Sanofi Pasteur
Modality: Vaccines & Immunotherapeutics
Administration: Subcutaneous

Overview

**CYD dengue virus serotype 4 live attenuated antigen** is the dengue virus serotype 4 component of Sanofi's tetravalent live-attenuated dengue vaccine, Dengvaxia. It is a recombinant chimeric flavivirus built on the attenuated yellow fever 17D204 viral backbone, with the premembrane and envelope structural-protein sequences derived from dengue virus serotype 4. When delivered as part of Dengvaxia, it is intended to induce serotype 4-specific neutralizing immune responses and contribute to prevention of dengue disease caused by dengue virus serotypes 1 through 4 in previously dengue-infected individuals.

Other names: CYD dengue virus serotype 4 live attenuated antigenDengue virus serotype-4 1118 pre-membrane and envelope protein yellow fever 17D204 chimeric virus antigenDengue-yellow fever chimeric virus serotype 4 live attenuated antigen

Targets

CD209 (Dendritic cell-specific intercellular adhesion Molecule-3-Grabbing non-integrin)

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