Drug intelligence / Profile preview

cymbopogon schoenanthus ethanol extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Cymbopogon schoenanthus ethanol extract** is a non-approved botanical research extract prepared from *Cymbopogon schoenanthus*, a lemongrass species. It is a complex phytochemical mixture rather than a single defined active pharmaceutical ingredient, with reported constituents including tannins, saponins, flavonoids, alkaloids, triterpenes, steroids, volatile oils, and terpene-rich fractions. Preclinical studies have investigated it for antistress and antidepressant-like effects, nephroprotective activity in kidney stone models, anti-obesity effects, antimicrobial activity, and in vitro anticancer activity. Its pharmacology appears pleiotropic and incompletely defined; reported biological effects include modulation of heat shock proteins such as HSP27 and HSP90, effects on corticosterone and catecholamine signaling, regulation of lipogenic and thermogenic proteins including UCP1, and possible anticancer activity linked to terpene constituents with in silico affinity for Polo-like kinase 1. There is no evidence in the provided context of formal clinical development, regulatory approval, or commercialization by a pharmaceutical company.

Other names
cymbopogon schoenanthus ethanol extractCymbopogon schoenanthus aerial part ethanol extractCymbopogon schoenanthus L. aerial part ethanol extract
02

Targets

UCP1 (Uncoupling protein 1)HSP90AA1 (Heat shock protein HSP90-alpha)HSPB1 (Heat shock protein beta-1)PLK1 (Polo like kinase 1)

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