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CYN-101
- Development stage
- Preclinical
- Lead developer
- Cynvec
- Modality
- Viral Vectors → Gene Addition/Replacement → Gene Therapies, Oncolytic Viruses → Oncolytic Therapeutics
- Administration
- Intravenous
01
Overview
CYN-101 is an investigational apoptosis-stimulating viral vector therapy developed by Cynvec. It is based on a Sindbis virus (SIN) platform, which leverages the natural tropism of the virus for cells overexpressing the 67-kDa high-affinity laminin receptor (LAMR), a protein frequently upregulated in various cancers. Upon entering the target cell, the viral vector replicates and induces programmed cell death (apoptosis). CYN-101 is being developed for the treatment of neoplasms, endocrine and metabolic diseases, and urogenital disorders. The program is currently in the early stages of development, with its global R&D status often characterized as pending or in the pre-clinical phase.
- Other names
- Sindbis virus vector
02
Targets
RPSA (37/67 kDa laminin receptor)
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