CYN154806

CYN154806 is a cyclic octapeptide that acts as a potent and highly selective antagonist of the somatostatin receptor subtype 2 (SSTR2). It exhibits high affinity for human recombinant SSTR2 (pIC50 of 8.58) with significantly lower affinity for other somatostatin receptor subtypes (SSTR1, SSTR3, SSTR4, and SSTR5). CYN154806 is widely utilized as a pharmacological research tool to investigate the physiological roles of SSTR2, particularly in regulating hormone secretion. In preclinical studies, it has been shown to restore hypoglycemia-induced glucagon secretion in models of type 1 diabetes by blocking the inhibitory paracrine effects of somatostatin on pancreatic alpha-cells.

Other names

(4R,7S,10S,13R,16S,19S)-19-[[(2S)-2-acetamido-3-(4-nitrophenyl)propanoyl]amino]-10-(4-aminobutyl)-N-[(2R)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamideAc-(4-NO2-Phe)-cyc(DCys-Tyr-DTrp-Lys-Thr-Cys)-DTyr-NH2Cyanamid 154806Cyanamid154806Cyanamid-154806D-Tyr8 cyanamid 154806D-Tyr-8 cyanamid 154806D-Tyr 8 cyanamid 154806D-Tyr8-CYN154806D-Tyr-8-CYN154806D-Tyr 8-CYN154806