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cynanchum atratum
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Cynanchum atratum, known in traditional Chinese medicine as Baiwei, is a perennial herb from the Apocynaceae family that has been utilized for over 2,000 years for its antipyretic, anti-inflammatory, and diuretic properties. The medicinal portion consists of the dried root and rhizome, which contain a diverse array of bioactive C21 steroidal saponins. Traditionally, it is indicated for the treatment of yin-deficiency fever, postpartum fever, urinary tract infections, and inflammatory skin conditions such as atopic dermatitis. Modern pharmacological research has explored its potential in metabolic health, specifically for non-alcoholic fatty liver disease (NAFLD) through the activation of the AMPK pathway, and in dermatology for its anti-melanogenic effects mediated via the cAMP/MITF signaling pathway. It is typically administered as a botanical extract rather than a purified pharmaceutical compound.
- Other names
- BaiweiCynanchi Atrati Radix et Rhizoma白薇
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)MITF (Melanocyte inducing transcription factor)
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