Drug intelligence / Profile preview

cynara scolymus

Development stage
Preclinical
Lead developer
Shandong Provincial Science and Technology Office
Administration
Oral
01

Overview

**Cynara scolymus** is artichoke, typically used in drug and clinical-study contexts as an oral **plant extract** or standardized **artichoke leaf extract** rather than as a single defined small-molecule active pharmaceutical ingredient. Publicly available clinical literature cited in the provided context supports investigation of standardized *Cynara scolymus* extracts for metabolic disorders such as impaired fasting glucose, where effects have been attributed to phytochemical constituents including chlorogenic acid and dicaffeoylquinic acid derivatives that may inhibit glucose 6-phosphate translocase and modulate alpha-glucosidase activity. The supplied trial context also places artichoke-containing fermented plant drinks in clinical development for alcoholic liver disease. Overall, this entry is best understood as a botanical nutraceutical or dietary-supplement ingredient with heterogeneous compositions across products, not as a single approved pharmaceutical entity with one uniform manufacturer or developer.

Other names
artichokeartichoke leaf extractCynara scolymus extract
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)ABCC2 (ATP-binding cassette sub-family C member 2)

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