cynarine

Cynarine is a naturally occurring **small molecule phenolic compound** isolated from artichoke and best known chemically as **1,3-dicaffeoylquinic acid**. It is not a modern proprietary pipeline asset from a single biotech developer, but rather a plant-derived bioactive that has appeared in historical pharmaceutical products and remains available as a research chemical and as a constituent of artichoke-based nutraceutical preparations. Reported activities include **cholagogue and choleretic effects** that promote bile secretion, along with antioxidant, hepatoprotective, antihistaminic, antiviral, and antilipemic properties. Mechanistic literature cited in the provided context indicates effects on **CD28 of T-cell receptors**, induction of **Nrf2 nuclear translocation**, restoration of glutathione and reactive oxygen species balance, and inhibition of mitochondrial depolarization. It has been investigated or used in contexts such as digestive disorders, hypercholesterolemia, and non-alcoholic fatty liver disease, although evidence is heterogeneous and cynarine is better characterized as a natural product and nutraceutical ingredient than as a currently developed prescription pharmaceutical.

Brand names

Cynarine 75Cynarine75Cynarine-75

Other names

cynarin1,3-dicaffeoylquinic acid