Drug intelligence / Profile preview

Cynodon dactylon allergen extract

Development stage
Phase 2
Lead developer
ALK Abelló
Modality
Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intradermal, Percutaneous, Subcutaneous, Sublingual
01

Overview

Cynodon dactylon allergen extract, commonly known as Bermuda grass pollen extract, is a standardized biological allergen extract used for both the diagnosis and treatment of IgE-mediated allergies to Bermuda grass (Cynodon dactylon). The extract contains water-soluble proteins and other bioactive molecules from Cynodon dactylon pollen, with the major allergenic component identified as Cyn d 1. It is formulated as sterile solutions for administration. For diagnostic purposes, it is used in skin prick or intradermal testing to identify sensitivity. For therapeutic purposes, it is administered as allergen-specific immunotherapy (either subcutaneously or sublingually) to modulate the patient's immune response, reducing symptoms of allergic rhinitis, seasonal allergies, and asthma. The mechanism of action involves inducing immunological tolerance, characterized by changes in allergen-specific IgE levels and an increase in IgG blocking antibodies.

Brand names
APiORALAPiPRICKCenter-Al
Other names
Bermuda grass allergen extractBermuda grass pollen allergen extractBermuda grass pollen extractCynodon dactylon pollenCynodon dactylon pollen extractStandardized Bermuda Grass Pollen
02

Targets

IgE (Immunoglobulin E)

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