Drug intelligence / Profile preview

cyproheptadine + sorbitol + tricholine citrate

Development stage
Unknown
Lead developer
Caplet India
Modality
Small Molecules
Administration
Oral
01

Overview

Choliv is an oral combination therapy developed by Caplet India, formulated as a syrup or drops, containing cyproheptadine, tricholine citrate, and sorbitol. It is primarily indicated as an appetite stimulant and digestive aid to treat anorexia, support weight gain, and manage malnutrition in both children and adults. Cyproheptadine acts as an antihistamine and serotonin antagonist, targeting the hypothalamus to stimulate appetite. Tricholine citrate serves as a lipotropic and bile acid-binding agent that mobilizes fat from the liver, supporting hepatic function and improving digestion. Sorbitol acts as an osmotic laxative to prevent constipation and serves as a pharmaceutical syrup base. Choliv is approved and marketed in India.

Brand names
CholivCholiv DropCholiv LCholiv Syrup
Other names
cyproheptadine + tricholine citrate + sorbitolcyproheptadine, sorbitol and tricholine citratecyproheptadine, tricholine citrate and sorbitol
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)AR (Adrenergic receptors)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)

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