cyproterone acetate + ethinylestradiol + metformin

A combination therapy used primarily for treating polycystic ovary syndrome (PCOS). This combination addresses multiple aspects of PCOS: - **Cyproterone acetate**: A steroidal antiandrogen that blocks androgen production in the ovaries, reducing hirsutism and acne - **Ethinylestradiol**: An estrogen that enhances cyproterone's effects by further reducing androgen levels and regularizing menstrual cycles - **Metformin**: An insulin sensitizer that improves metabolic parameters and may further suppress hyperandrogenemia Clinical studies show this combination provides better and faster decreases in testosterone levels and free androgen index compared to cyproterone acetate/ethinylestradiol alone, without deteriorating anthropometric indices or insulin sensitivity.

Brand names

Diane-35 + metformin

Other names

metformin + oral contraceptivemetformin + Diane-35metformin + CPA/EE