Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
cys-monomethyl auristatin F
- Development stage
- Unknown
- Lead developer
- Skagen
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous, Intramuscular, Intradermal, Intraperitoneal, Subcutaneous
01
Overview
cys-monomethyl auristatin F is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization, leading to cell cycle arrest and apoptosis. It is derived from dolastatin 10. Due to its high toxicity, it cannot be used as a standalone drug and is primarily employed as a cytotoxic payload within Antibody-Drug Conjugates (ADCs). The "cys" prefix indicates a cysteine-linked form, often through a maleimidocaproyl (mc) linker, which is the active species released from certain ADCs upon internalization into cancer cells.
- Other names
- Monomethylauristatin Fcysteine maleimidocaproyl monomethyl auristatin F
02
Targets
TUBB (Tubulin (alpha and beta subunits))
Beyond the preview
Go deeper on cys-monomethyl auristatin F.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cys-monomethyl auristatin F.