cystamine

Cystamine is a low-molecular-weight thiol and the oxidized disulfide form of cysteamine. It has been studied primarily as an experimental agent, in part for its ability to inhibit transglutaminase enzymes and modulate redox status. Cystamine can also increase intracellular levels of cysteine and has demonstrated neuroprotective properties in various preclinical models, including models of neurodegenerative diseases such as Huntington's disease and Parkinson's disease. The principal mechanism involves modulation of cysteine metabolism and inhibition of transglutaminase. Cystamine itself is not approved as a pharmaceutical drug for any indication, but its reduced form (cysteamine) is approved and widely used, especially in nephropathic cystinosis[4].

Other names

2,2'-dithiobis(ethylamine)cystamine dihydrochloride