Drug intelligence / Profile preview

CYT005-AllQbG10

Development stage
Phase 2
Lead developer
Kuros Biosciences
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

**CYT005-AllQbG10** was a Cytos Biotechnology allergen-immunotherapy vaccine program combining CYT003-QbG10 with a selected natural allergen extract, including house dust mite or grass-pollen extracts in separate clinical studies. CYT003-QbG10 consists of bacteriophage Qbeta-derived virus-like particles containing the CpG oligodeoxynucleotide G10, an endosomal Toll-like receptor 9 agonist intended to shift allergic immune responses away from pathogenic T-helper-2 polarization while allergen exposure promotes antigen-specific desensitization. The program was administered as a subcutaneous suspension and reached Phase 2 studies in allergic rhinoconjunctivitis, house dust mite allergy, grass-pollen allergy, and allergic asthma before being discontinued. ([ichgcp.net](https://ichgcp.net/clinical-trials-registry/NCT00574704))

Brand names
CYT005-AllQbG10CYT-005-AllQbG10CYT 005-AllQbG10
Other names
AllQbG10AllQbG-10AllQbG 10CYT003-QbG10 combination vaccineCYT-003-QbG10 combination vaccineCYT 003-QbG10 combination vaccineCYT005 AllQbG10CYT-005 AllQbG10CYT 005 AllQbG10CYT005AllQbG10CYT-005AllQbG10CYT 005AllQbG10
02

Targets

TLR9 (Toll-like receptor 9)

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