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cytokine-induced killer cells
- Development stage
- Unknown
- Lead developer
- Yanjuan Zhu
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
Cytokine-induced killer (CIK) cells are an autologous, ex vivo-expanded population of immune effector cells, primarily characterized by a CD3+CD56+ phenotype. They are generated from a patient's peripheral blood mononuclear cells (PBMCs) through stimulation with interferon-gamma (IFN-γ), interleukin-2 (IL-2), and anti-CD3 antibodies. This cell therapy combines the potent anti-tumor activity of T cells with the non-MHC-restricted cytotoxicity of natural killer (NK) cells. In the context of colon cancer, specifically stage II/III, CIK cells are investigated as an adjuvant immunotherapy following surgical resection and chemotherapy to eliminate residual micrometastases and reduce recurrence rates. The therapy was notably studied in a Phase 2 clinical trial (NCT01800058) led by Yanjuan Zhu, which evaluated the efficacy of CIK cell transfusion in prolonging disease-free survival and overall survival.
- Other names
- CIK cellsautologous cytokine-induced killer cellsadjuvant CIK immunotherapy
02
Targets
MICB (Major histocompatibility complex class i-related protein B)FASN (Fatty acid synthase)FCGR3B (Fc gamma receptor III)
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