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Drug intelligence / Profile preview
cytomegalovirus pp65-lysosome-associated membrane glycoprotein ribonucleic acid-pulsed dendritic cell vaccine
- Development stage
- Unknown
- Lead developer
- Duke University Medical Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intradermal
01
Overview
**Cytomegalovirus pp65-lysosome-associated membrane glycoprotein ribonucleic acid-pulsed dendritic cell vaccine** is an autologous dendritic cell-based therapeutic cancer vaccine developed primarily at Duke University for glioblastoma and studied in both adult and pediatric malignant brain tumors. The product is generated from patient-derived mature dendritic cells electroporated or pulsed with messenger RNA encoding a fusion of the human cytomegalovirus phosphoprotein 65 antigen and lysosome-associated membrane glycoprotein 1, a design intended to enhance antigen processing and presentation through major histocompatibility complex pathways. After intradermal administration, often with granulocyte-macrophage colony-stimulating factor as an admixed adjuvant, the vaccine is intended to prime and expand CMV pp65-specific antitumor T-cell responses against CMV pp65-expressing glioma cells. It is a personalized biologic cell therapy and therapeutic vaccine rather than a prophylactic antiviral vaccine.
- Other names
- cytomegalovirus pp65-lysosome-associated membrane glycoprotein ribonucleic acid-pulsed dendritic cell vaccineCMV pp65-LAMP mRNA-pulsed dendritic cell vaccinepp65-LAMP mRNA-pulsed dendritic cell vaccinepp-65-LAMP mRNA-pulsed dendritic cell vaccinepp 65-LAMP mRNA-pulsed dendritic cell vaccineautologous pp65-LAMP mRNA-pulsed dendritic cell vaccinecytomegalovirus pp65 dendritic cell vaccine
02
Targets
pp65 (Cytomegalovirus phosphoprotein 65)
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