cytomegalovirus-specific cytotoxic t lymphocytes

Cytomegalovirus-specific cytotoxic T lymphocytes (CMV-specific CTLs) are a form of adoptive cell therapy consisting of T cells that have been sensitized and expanded ex vivo to specifically recognize and kill cells infected with human cytomegalovirus (CMV). These cells are typically generated from seropositive donors or from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products. The primary mechanism involves the recognition of CMV antigens presented on infected cells via HLA molecules, leading to targeted lysis of these cells. Adoptive transfer of these CTLs is used as a therapeutic strategy to treat or prevent CMV reactivation and disease, particularly in immunocompromised patients such as those undergoing allogeneic hematopoietic stem cell transplantation[8][9][10]. This approach can restore antiviral immunity without causing graft-versus-host disease.

Other names

CMV-specific cytotoxic T lymphocytesCMV-specific CTLscytomegalovirus-specific CTLs